Driven Flow® Technology
immunochemical Fecal Occult Blood (iFOB) Tests for Colorectal Cancer Prescreening
Features & Benefits of ALFA’s patented SplitScreen Urine Cup Test:
From the earliest commercial kits used to test for pregnancy, to recent regulatory clearance allowing for home collection of samples for the early detection of colorectal cancer, lateral flow technology has remained the standard bearer in immunological, point-of-care testing. Predicated on the ability of antibodies to specifically bind both large proteins and analytes as small as traditional drugs and their metabolites, the range of possible targets for development of a lateral flow assay is nearly limitless.
While ubiquitous and convenient, traditional lateral flow technology is hampered by issues with sensitivity and accuracy. When considering a complex matrix such as saliva, these shortfalls are compounded and analysis times can increase to 20 minutes or more. By employing patented technologies, ALFA seeks to solve these problems without altering the sensitive chemistries involved in analyte detection.
Driven Flow™ Technology utilizes powerful driving forces to push the flow evenly past the reaction area at highly accelerated speeds. With the force of Driven Flow™ Technology, users can experience the following benefits:
Driven Flow® Technology represents a breakthrough in point-of- care (POC), rapid diagnostic testing. By greatly enhancing the speed, accuracy, and specificity of the canonical lateral flow assay, the patented Driven Flow® Technology offers a route to true confirmatory and quantitative POC testing for pathogens, drugs and their metabolites, hormones, and other antigens in a wide array of testing environments. With reliable results in as little as one minute, Driven Flow® Technology delivers on the “Accuracy at the Speed of ALFA” promise.
The patented Driven Flow® Technology utilizes a tightly restricted sample flow-path and the additional flow acceleration, termed Driven Flow®, provided by mechanically squeezing the liquid sample matrix through the device. Much like the pump used in High Performance Liquid Chromatography (HPLC), this squeezing action produces the powerful driving force to push the flow past the reaction area evenly, at high speed while generating maximum, thorough reaction of the binding complexes. This flow also provides a strong self-washing function that minimizes non-specific binding in the reaction area.